Hyaluronate‐alginate gel as a novel biomaterial: Mechanical properties and formation mechanism
Identifieur interne : 001D25 ( Main/Exploration ); précédent : 001D24; suivant : 001D26Hyaluronate‐alginate gel as a novel biomaterial: Mechanical properties and formation mechanism
Auteurs : Sandra Oerther [France] ; Hervé Le Gall [France] ; Elisabeth Payan [France] ; François Lapicque [France] ; Nathalie Presle [France] ; Patrick Hubert [France] ; Jean Dexheimer [France] ; Patrick Netter [France] ; Françoise Lapicque [France]Source :
- Biotechnology and Bioengineering [ 0006-3592 ] ; 1999-04-20.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Biomatériau, Calcium, Industrie pharmaceutique, Polymère.
English descriptors
- KwdEn :
- Actual alginate concentration, Alginate, Alginate content, Alginate solutions, Alginates, Alginic acid, Aqueous solution, Average temperature, Average weight, Bead, Beads, Biologie forestiere, Biomaterial, Calcium, Calcium chloride medium, Calcium chloride solution, Calcium content, Calcium contents, Calcium diffusion, Calcium figure, Calcium ions, Calcium medium, Characteristic viscosity, Classical problem, Coefficient, Complementary error function, Confidence intervals, Continuous sphere, Dialysis cell, Diffusion coefficient, Diffusion coefficients, Diffusion phenomena, Diffusion process, Diffusion rates, Divalent cations, Drug carrier, Experimental data, Experimental procedure, Experimental variations, First hour, Freeze, Gelation, Gelation mechanism, Gelation time, Generalised model, Good agreement, Guluronic, Guluronic acid, Hardness, Hyaluronate, Hyaluronate content, Hyaluronate loss, Hyaluronate salts, Hyaluronate solutions, Hyaluronic, Hyaluronic acid, Industrial application, Infinite dilution, Instantaneous compliance, John wiley sons, Lower extent, Mechanical properties, Medical application, Molecular weight, Objective function, Oerther, Pharmaceutical industry, Physical properties, Polymer, Polysaccharide, Polysaccharide mixtures, Polysaccharidic chains, Preliminary experiments, Pure alginate, Relaxation period, Rheological, Rheological measurements, Rheological properties, Rooster comb, Rooster comb hyaluronate, Saturation chamber, Significant loss, Simple model, Small pores, Sodium alginate, Sodium hyaluronate, Specific interactions, Spherical beads, Synovial fluid, Thermal diffusivity, Thick slabs, Time variation, Transient diffusion, Ultrapure water, Various species, Water content, Water loss, Water transport, Weight loss, Weight ratio, Weight ratios, Wound healing.
- Teeft :
- Actual alginate concentration, Alginate, Alginate content, Alginate solutions, Alginic acid, Aqueous solution, Average temperature, Average weight, Bead, Beads, Biologie forestiere, Calcium, Calcium chloride medium, Calcium chloride solution, Calcium content, Calcium contents, Calcium diffusion, Calcium figure, Calcium ions, Calcium medium, Characteristic viscosity, Classical problem, Coefficient, Complementary error function, Confidence intervals, Continuous sphere, Dialysis cell, Diffusion coefficient, Diffusion coefficients, Diffusion phenomena, Diffusion rates, Divalent cations, Drug carrier, Experimental data, Experimental procedure, Experimental variations, First hour, Gelation, Gelation mechanism, Gelation time, Generalised model, Good agreement, Guluronic, Guluronic acid, Hardness, Hyaluronate, Hyaluronate content, Hyaluronate loss, Hyaluronate salts, Hyaluronate solutions, Hyaluronic, Hyaluronic acid, Infinite dilution, Instantaneous compliance, John wiley sons, Lower extent, Mechanical properties, Molecular weight, Objective function, Oerther, Physical properties, Polymer, Polysaccharide, Polysaccharide mixtures, Polysaccharidic chains, Preliminary experiments, Pure alginate, Relaxation period, Rheological, Rheological measurements, Rooster comb, Rooster comb hyaluronate, Saturation chamber, Significant loss, Simple model, Small pores, Sodium alginate, Sodium hyaluronate, Specific interactions, Spherical beads, Synovial fluid, Thermal diffusivity, Thick slabs, Time variation, Transient diffusion, Ultrapure water, Various species, Water content, Water loss, Water transport, Weight loss, Weight ratio, Weight ratios, Wound healing.
Abstract
With the aim of producing a biomaterial for surgical applications, the alginate–hyaluronate association has been investigated to combine the gel‐forming properties of alginate with the healing properties of hyaluronate. Gels were prepared by diffusion of calcium into alginate–hyaluronate mixtures, with an alginate content of 20 mg/mL. The hyaluronate source was shown to have significant effect on the aspect and the properties of the gels. The gels have viscoelastic behaviour and the transient measurements carried out in creep mode could be interpreted through a Kelvin–Voigt generalised model: experimental data led to the steady state hardness and a characteristic viscosity of the gel. Gels prepared from Na rooster comb hyaluronate with weight ratio up to 0.50 have satisfactory mechanical properties, and fully stable gels are obtained after a few days; on the contrary, use of lower molecular weight hyaluronate led to loose gels for hyaluronate contents over 0.25. Gel formation was investigated by measurements of the exchange fluxes between the calcium chloride solution and the forming gel, which allowed thorough investigations of the occuring diffusion phenomena of water, calcium ion and hyaluronate. Strong interactions of water with hyaluronate reduce significantly the rate of weight loss from the gel beads and allows higher water content in steady‐state gels. Calcium content in the gel samples could be correlated to the actual alginate concentration, whatever the nature and the weight ratio of hyaluronate. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 206–215, 1999.
Url:
DOI: 10.1002/(SICI)1097-0290(19990420)63:2<206::AID-BIT9>3.0.CO;2-8
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy, Vandoeuvre les Nancy, Vandœuvre les Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000212
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- to stream Istex, to step Checkpoint: 000824
- to stream Main, to step Merge: 002085
- to stream PascalFrancis, to step Corpus: 000B91
- to stream PascalFrancis, to step Curation: 001353
- to stream PascalFrancis, to step Checkpoint: 000B27
- to stream Main, to step Merge: 002197
- to stream Main, to step Curation: 001D25
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actual alginate concentration</term>
<term>Alginate</term>
<term>Alginate content</term>
<term>Alginate solutions</term>
<term>Alginates</term>
<term>Alginic acid</term>
<term>Aqueous solution</term>
<term>Average temperature</term>
<term>Average weight</term>
<term>Bead</term>
<term>Beads</term>
<term>Biologie forestiere</term>
<term>Biomaterial</term>
<term>Calcium</term>
<term>Calcium chloride medium</term>
<term>Calcium chloride solution</term>
<term>Calcium content</term>
<term>Calcium contents</term>
<term>Calcium diffusion</term>
<term>Calcium figure</term>
<term>Calcium ions</term>
<term>Calcium medium</term>
<term>Characteristic viscosity</term>
<term>Classical problem</term>
<term>Coefficient</term>
<term>Complementary error function</term>
<term>Confidence intervals</term>
<term>Continuous sphere</term>
<term>Dialysis cell</term>
<term>Diffusion coefficient</term>
<term>Diffusion coefficients</term>
<term>Diffusion phenomena</term>
<term>Diffusion process</term>
<term>Diffusion rates</term>
<term>Divalent cations</term>
<term>Drug carrier</term>
<term>Experimental data</term>
<term>Experimental procedure</term>
<term>Experimental variations</term>
<term>First hour</term>
<term>Freeze</term>
<term>Gelation</term>
<term>Gelation mechanism</term>
<term>Gelation time</term>
<term>Generalised model</term>
<term>Good agreement</term>
<term>Guluronic</term>
<term>Guluronic acid</term>
<term>Hardness</term>
<term>Hyaluronate</term>
<term>Hyaluronate content</term>
<term>Hyaluronate loss</term>
<term>Hyaluronate salts</term>
<term>Hyaluronate solutions</term>
<term>Hyaluronic</term>
<term>Hyaluronic acid</term>
<term>Industrial application</term>
<term>Infinite dilution</term>
<term>Instantaneous compliance</term>
<term>John wiley sons</term>
<term>Lower extent</term>
<term>Mechanical properties</term>
<term>Medical application</term>
<term>Molecular weight</term>
<term>Objective function</term>
<term>Oerther</term>
<term>Pharmaceutical industry</term>
<term>Physical properties</term>
<term>Polymer</term>
<term>Polysaccharide</term>
<term>Polysaccharide mixtures</term>
<term>Polysaccharidic chains</term>
<term>Preliminary experiments</term>
<term>Pure alginate</term>
<term>Relaxation period</term>
<term>Rheological</term>
<term>Rheological measurements</term>
<term>Rheological properties</term>
<term>Rooster comb</term>
<term>Rooster comb hyaluronate</term>
<term>Saturation chamber</term>
<term>Significant loss</term>
<term>Simple model</term>
<term>Small pores</term>
<term>Sodium alginate</term>
<term>Sodium hyaluronate</term>
<term>Specific interactions</term>
<term>Spherical beads</term>
<term>Synovial fluid</term>
<term>Thermal diffusivity</term>
<term>Thick slabs</term>
<term>Time variation</term>
<term>Transient diffusion</term>
<term>Ultrapure water</term>
<term>Various species</term>
<term>Water content</term>
<term>Water loss</term>
<term>Water transport</term>
<term>Weight loss</term>
<term>Weight ratio</term>
<term>Weight ratios</term>
<term>Wound healing</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Alginate</term>
<term>Application industrielle</term>
<term>Application médicale</term>
<term>Biomatériau</term>
<term>Gel</term>
<term>Hyaluronique acide</term>
<term>Industrie pharmaceutique</term>
<term>Processus diffusion</term>
<term>Propriété rhéologique</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Actual alginate concentration</term>
<term>Alginate</term>
<term>Alginate content</term>
<term>Alginate solutions</term>
<term>Alginic acid</term>
<term>Aqueous solution</term>
<term>Average temperature</term>
<term>Average weight</term>
<term>Bead</term>
<term>Beads</term>
<term>Biologie forestiere</term>
<term>Calcium</term>
<term>Calcium chloride medium</term>
<term>Calcium chloride solution</term>
<term>Calcium content</term>
<term>Calcium contents</term>
<term>Calcium diffusion</term>
<term>Calcium figure</term>
<term>Calcium ions</term>
<term>Calcium medium</term>
<term>Characteristic viscosity</term>
<term>Classical problem</term>
<term>Coefficient</term>
<term>Complementary error function</term>
<term>Confidence intervals</term>
<term>Continuous sphere</term>
<term>Dialysis cell</term>
<term>Diffusion coefficient</term>
<term>Diffusion coefficients</term>
<term>Diffusion phenomena</term>
<term>Diffusion rates</term>
<term>Divalent cations</term>
<term>Drug carrier</term>
<term>Experimental data</term>
<term>Experimental procedure</term>
<term>Experimental variations</term>
<term>First hour</term>
<term>Gelation</term>
<term>Gelation mechanism</term>
<term>Gelation time</term>
<term>Generalised model</term>
<term>Good agreement</term>
<term>Guluronic</term>
<term>Guluronic acid</term>
<term>Hardness</term>
<term>Hyaluronate</term>
<term>Hyaluronate content</term>
<term>Hyaluronate loss</term>
<term>Hyaluronate salts</term>
<term>Hyaluronate solutions</term>
<term>Hyaluronic</term>
<term>Hyaluronic acid</term>
<term>Infinite dilution</term>
<term>Instantaneous compliance</term>
<term>John wiley sons</term>
<term>Lower extent</term>
<term>Mechanical properties</term>
<term>Molecular weight</term>
<term>Objective function</term>
<term>Oerther</term>
<term>Physical properties</term>
<term>Polymer</term>
<term>Polysaccharide</term>
<term>Polysaccharide mixtures</term>
<term>Polysaccharidic chains</term>
<term>Preliminary experiments</term>
<term>Pure alginate</term>
<term>Relaxation period</term>
<term>Rheological</term>
<term>Rheological measurements</term>
<term>Rooster comb</term>
<term>Rooster comb hyaluronate</term>
<term>Saturation chamber</term>
<term>Significant loss</term>
<term>Simple model</term>
<term>Small pores</term>
<term>Sodium alginate</term>
<term>Sodium hyaluronate</term>
<term>Specific interactions</term>
<term>Spherical beads</term>
<term>Synovial fluid</term>
<term>Thermal diffusivity</term>
<term>Thick slabs</term>
<term>Time variation</term>
<term>Transient diffusion</term>
<term>Ultrapure water</term>
<term>Various species</term>
<term>Water content</term>
<term>Water loss</term>
<term>Water transport</term>
<term>Weight loss</term>
<term>Weight ratio</term>
<term>Weight ratios</term>
<term>Wound healing</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Biomatériau</term>
<term>Calcium</term>
<term>Industrie pharmaceutique</term>
<term>Polymère</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">With the aim of producing a biomaterial for surgical applications, the alginate–hyaluronate association has been investigated to combine the gel‐forming properties of alginate with the healing properties of hyaluronate. Gels were prepared by diffusion of calcium into alginate–hyaluronate mixtures, with an alginate content of 20 mg/mL. The hyaluronate source was shown to have significant effect on the aspect and the properties of the gels. The gels have viscoelastic behaviour and the transient measurements carried out in creep mode could be interpreted through a Kelvin–Voigt generalised model: experimental data led to the steady state hardness and a characteristic viscosity of the gel. Gels prepared from Na rooster comb hyaluronate with weight ratio up to 0.50 have satisfactory mechanical properties, and fully stable gels are obtained after a few days; on the contrary, use of lower molecular weight hyaluronate led to loose gels for hyaluronate contents over 0.25. Gel formation was investigated by measurements of the exchange fluxes between the calcium chloride solution and the forming gel, which allowed thorough investigations of the occuring diffusion phenomena of water, calcium ion and hyaluronate. Strong interactions of water with hyaluronate reduce significantly the rate of weight loss from the gel beads and allows higher water content in steady‐state gels. Calcium content in the gel samples could be correlated to the actual alginate concentration, whatever the nature and the weight ratio of hyaluronate. © 1999 John Wiley & Sons, Inc. Biotechnol Bioeng 63: 206–215, 1999.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Grand Est</li>
<li>Lorraine (région)</li>
</region>
<settlement><li>Nancy</li>
<li>Vandoeuvre les Nancy</li>
<li>Vandœuvre les Nancy</li>
</settlement>
<orgName><li>Centre national de la recherche scientifique</li>
<li>Laboratoire réactions et génie des procédés</li>
<li>Université de Lorraine</li>
</orgName>
</list>
<tree><country name="France"><region name="Grand Est"><name sortKey="Oerther, Sandra" sort="Oerther, Sandra" uniqKey="Oerther S" first="Sandra" last="Oerther">Sandra Oerther</name>
</region>
<name sortKey="Dexheimer, Jean" sort="Dexheimer, Jean" uniqKey="Dexheimer J" first="Jean" last="Dexheimer">Jean Dexheimer</name>
<name sortKey="Hubert, Patrick" sort="Hubert, Patrick" uniqKey="Hubert P" first="Patrick" last="Hubert">Patrick Hubert</name>
<name sortKey="Lapicque, Francois" sort="Lapicque, Francois" uniqKey="Lapicque F" first="François" last="Lapicque">François Lapicque</name>
<name sortKey="Lapicque, Francois" sort="Lapicque, Francois" uniqKey="Lapicque F" first="François" last="Lapicque">François Lapicque</name>
<name sortKey="Lapicque, Francois" sort="Lapicque, Francois" uniqKey="Lapicque F" first="François" last="Lapicque">François Lapicque</name>
<name sortKey="Lapicque, Francoise" sort="Lapicque, Francoise" uniqKey="Lapicque F" first="Françoise" last="Lapicque">Françoise Lapicque</name>
<name sortKey="Lapicque, Francoise" sort="Lapicque, Francoise" uniqKey="Lapicque F" first="Françoise" last="Lapicque">Françoise Lapicque</name>
<name sortKey="Lapicque, Francoise" sort="Lapicque, Francoise" uniqKey="Lapicque F" first="Françoise" last="Lapicque">Françoise Lapicque</name>
<name sortKey="Le Gall, Herve" sort="Le Gall, Herve" uniqKey="Le Gall H" first="Hervé" last="Le Gall">Hervé Le Gall</name>
<name sortKey="Netter, Patrick" sort="Netter, Patrick" uniqKey="Netter P" first="Patrick" last="Netter">Patrick Netter</name>
<name sortKey="Netter, Patrick" sort="Netter, Patrick" uniqKey="Netter P" first="Patrick" last="Netter">Patrick Netter</name>
<name sortKey="Payan, Elisabeth" sort="Payan, Elisabeth" uniqKey="Payan E" first="Elisabeth" last="Payan">Elisabeth Payan</name>
<name sortKey="Presle, Nathalie" sort="Presle, Nathalie" uniqKey="Presle N" first="Nathalie" last="Presle">Nathalie Presle</name>
</country>
</tree>
</affiliations>
</record>
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